new01

NeoTrident passed ISO27001 certification, information security management capability is internationally recognized!

by CompanyNews Center

Recently, Beijing NeoTrident and its holding company Suzhou NeoTrident Software Co., Ltd. have officially passed the ISO/IEC 27001:2013 (Information Security Management System) certification audited by BSI (British Standards Institution)! This international certification not only indicates that Trunet’s information security protection ability has been recognized by international authoritative organizations, but also means that Trunet, as an information technology enterprise, is more secure and reliable while taking into account high quality and efficiency.

In recent years, the rapid development and popularization of information technology has brought unprecedented changes to human life, production methods and business models, while some brand-new risks of network threats, data leakage and frauds also come along. Therefore, in order to obtain guaranteed information technology services, security capability is the top priority.

NeoTrident has been focusing on the development and innovation of information technology in the field of life sciences and material sciences for nearly two decades, and has provided more than 1,000 R&D institutes/enterprises in China with a full range of comprehensive information technology solutions and services, including computational simulation and data modeling, scientific research and innovation and quality compliance, which have helped users to improve their management, decision-making, and innovation in the fields of research and development, process, testing, production, etc. NeoTrident has been trusted by the industry for a long time and has been able to provide a wide range of information technology solutions and services. As a long-time trusted informationization and digitalization service partner of industrial customers, Trunsun is constantly improving and upgrading its own information security management level while putting forward higher requirements on the company’s products, technologies and service levels. The ISO/IEC 27001:2013 (Information Security Management System) certification is also an audit and certification for the whole process and business line within Trunsun.

ISO27001 certification is regarded as a rigorous, authoritative and widely accepted and applied system certification standard in the field of information security in the international arena. It carries out multi-dimensional assessment from the aspects of organization management, cryptographic control, human resources security, asset management, access control, physical and environmental security, and operational security, etc., which requires the enterprises to construct a high-specification information security system, and to ensure the user’s Information security and high stability of operation system. The senior leadership of Trunsun attaches great importance to the construction of the information security management system, and all departments of the company work closely with each other to formulate a set of effective information security management system in strict accordance with the requirements of the system and in combination with the actual situation of the company. At present, a green security network has been fully spread in the company, covering the whole business process of the company’s various product lines, involving system development, testing, implementation, operation and maintenance, as well as security technology protection and so on.

It is worth mentioning that the passing of this certification also means that iLabPower Collaborative Innovation Cloud Community, a cloud computing-based scientific research collaboration and innovation platform under Chuangteng Technology, has stepped into the ranks of the domestic laboratory informationization management and security in the field of life science and materials science. iLabPower Collaborative Innovation Cloud Community covers: EDM Experimental Data Management System, PM Project Management System, CMS Compound Management System, CIM Project Management System, CMS Compound Management System, CIM Project Management System and CIM Project Management System, The iLabPower Collaborative Innovation Cloud Community is a digital collaboration platform covering: EDM Experimental Data Management System, PM Project Management System, CMS Compound Management System, CIMS Laboratory Material Management System, PMS Procurement Management System, and ILM Instrument Lifecycle Management System. All modules realize unified planning and reserved interfaces, solving the problem of data silos between systems. At present, this platform has been adopted by many domestic pharmaceutical companies, universities and research institutes.

Trunsun has always believed that only by continuously improving its comprehensive management level can it respond to today’s complex and changing external environment more comfortably and stand invincible in the fierce competition. Trunsun has been using ISO9001 quality management system to strengthen the quality management of products and services for ten years, and the successful certification of ISO27001:2013 information security management system is an even more solid step for Trunsun to promote the level of information security management and enhance the core competitiveness!

However, as the wave of information technology change comes, network information security will also face more new challenges, so it is a heavy responsibility to protect information security! Trunsun will always adhere to the security management policy of “improving security compliance, preventing all kinds of security risks, ensuring customer data security, and guaranteeing safe business operations”, and will continue to explore and optimize in a dynamic environment, actively fulfill the responsibility of maintaining customer information and data security, and solidify information security maintenance and management into all aspects of business operations, customer service, technology development, and so on. We also solidify the maintenance and management of information security into all aspects of business operation, customer service, and technology research and development.

dna-representation-collage

NeoTrident iLabPower Sequence Editor Efficiently Catalyzes Bio-New Drug Development

by CompanyNews Center

With the advent of the electronic lab notebook era, based on the standardized cross-team workflow, molecular biologists and chemists are able to promote the research and development of new drugs in a more synergistic and efficient way. However, in the field of biology industrial software, China is still in its infancy and currently relies mainly on foreign imports. Relying on foreign software has some potential drawbacks, mainly in terms of data security and R&D costs.

Data security: Using foreign software usually means that the user’s data will be sent to foreign servers, which may be intercepted during transmission or accessed by unauthorized third parties on the servers. This poses a very serious risk for data that contains sensitive information, such as patient genetic data and new drug development data. In addition, this can also lead to legal issues, as many countries and regions have strict regulations on data export.

R&D Costs: Foreign software usually charges higher fees, especially for some specialized biology research software. This constitutes a considerable burden for research institutions and enterprises, especially those with relatively tight funds. In addition to the direct purchase costs, foreign software may also bring some implied costs. For example, due to differences in the language and cultural background in which the software is used, users may need to invest extra time and effort to learn and familiarize themselves with its use. In addition, obtaining technical support may also become more difficult due to differences in time zones and languages.

Some researchers have tried to use dozens of open source software to transfer data, however, this method is complicated to operate, cannot guarantee data security, and the results are often unsatisfactory, wasting a lot of valuable time.

In order to meet the above challenges, Trunetech proposes a solution: iLabPower Sequence Editor. iLabPower Sequence Editor is an important part of iLabPower R&D management platform, which allows biologists to no longer be constrained by foreign software, and no longer need to put their data in foreign countries. It is equipped with visual sequence editing function, and at the same time, the design process can be recorded in the experimental record book.

 

Figure 1 | iLabPower Sequence Editor: a homegrown biological sequence design tool integrated in the electronic lab notebook.

 

iLabPower Sequence Editor supports the completion of the upstream and downstream processes from sequence creation, sequence editing to sequence validation in one go on the same platform. Taking plasmid construction, a common molecular biology experiment, as an example, the key steps in the classic process, including selecting target genes and vectors, designing primers for PCR amplification of target fragments, selecting appropriate endonuclease for pre-assembly cutting, and checking the product by sequencing results, can all be completed in iLabPower Sequence Editor. The multiple work steps are centralized in one platform, which guarantees the traceability and reproducibility of the data. The recent popularity of CRISPR and cyclic RNA construction have a similar sequence design process as plasmid construction, which is also a potential application scenario for iLabPower Sequence Editor.

 

Figure 2 | iLabPower Sequence Editor The Sequence Editor supports the top-to-bottom sequence design process from sequence creation, to sequence editing, to sequence verification.

Check out the details of iLabPower Sequence Editor 1.2, which will be released soon!

 

Create Sequences

The iLabPower Sequence Editor supports creating sequences in a variety of ways:

  • Importing fasta sequence files
  • Import a fasta sequence file, import a genbank or other annotated sequence file.
  •  Import a fasta sequence file Import a sequence file with annotations such as genbank

iLabPower Sequence Editor supports users to customize the labeling classification of each sequence in the electronic lab notebook, which can be adapted to the actual development scenario of each team for sequence management and searching. The design and modification process of each sequence is fully recorded in the electronic lab notebook, which realizes the fine control of data history in teamwork and guarantees the reproducibility of the experimental results.

After the sequence is imported, iLabPower Sequence Editor can automate the sequence processing, including generating sequence coordinates, switching sequence case, copying/replacing/inserting/deleting specified parts of the sequence, and searching and locating the sequence. In the editor, DNA sequences can be copied in various formats, including forward and reverse strand, or forward and reverse strand of corresponding RNA and protein sequences, which no longer requires users to calculate manually, avoiding manual errors in the basic and tedious process, and saving a lot of time that can be invested in meaningful data interpretation and design.

The common sequence analysis process starts from obtaining gene and vector sequences, usually the result of downloading or sequencing is a single-stranded sequence, which can be imported into iLabPower Sequence Editor to automatically generate complementary strands and construct double-stranded DNA sequences to support the subsequent design work.

The iLabPower Sequence Editor not only supports displaying and editing at the precision of specific base sequences, but also displays the sequence as a whole in the form of linear or circular maps. On the map, annotations, primers, digestion sites and other information can be displayed in a personalized way, which is convenient for the construction and design of plasmids, CRISPR, miRNA and other structures.

 

Figure 3 | iLabPower Sequence Editor creates, manages and visualizes sequences.

Nucleic acid sequence analysis

  •  DNA property calculation and primer design

iLabPower Sequence Editor automatically calculates basic DNA properties, including annealing temperature, GC content, and sequence length, etc., which is very convenient for primer design. iLabPower Sequence Editor also provides an automatic primer design function based on Primer3, which automatically generates pairs of primers or single primers under the sequence range and primer parameters specified by the user and displays primer property parameters for comparison and selection. The primer parameters are displayed for comparison and selection.

 

Figure 4 | Primer design with iLabPower Sequence Editor

  •  Enzymatic site display

In the construction of various vectors, the use of restriction endonucleases is the basic step of sequence shearing. iLabPower Sequence Editor automatically identifies the enzyme cleavage sites in the sequence based on the NEB-Enzyme Finder database and displays them on the sequence and map. You can also search for specific enzyme sites in the editor to speed up the design of sequence cuts and substitutions.

 

Figure 5 | Browsing and searching for cleavage sites with the iLabPower Sequence Editor.

  •  Open Reading Frame Recognition

In the process of gene expression, the existence of open reading frames is one of the main mechanisms that cause the diversity of gene expression, and the diversity of expression products has a significant impact on the quality control in the development of new drugs. iLabPower Sequence Editor can automatically identify the open reading frames, support the identification of multiple start codons, support the user to customize the minimum length of the translation product, and provide an intuitive visual display of the open reading frames. Figure 6 | Using iLabPower Sequence Editor

 

Figure 6 | ORF-based diverse expression analysis using iLabPower Sequence Editor

Amino acid sequence analysis

  •  Protein biochemical characterization

For translatable DNA sequences, iLabPower Sequence Editor can automatically translate them into amino acid sequences corresponding to codons, and support users to select amino acid sequence coordinates and color schemes.

For the generated amino acid sequences, iLabPower Sequence Editor can automatically analyze the amino acid components of proteins, list the percentage of each amino acid, and study the properties of proteins by protein composition analysis. In addition, it is also possible to categorize the amino acids according to their hydrophilic and hydrophobic properties, and find those hydrophobic groups that may be transmembrane regions. In turn, parameters such as isoelectric point, molecular weight, extinction coefficient, instability, etc. of proteins can also be analyzed to study protein properties in general.

 

  • Antibody Design

Antibody drugs are currently a popular research area for new drugs. iLabPower Sequence Editor can automatically identify the CDR region in the sequence, i.e. the highly variable region that plays a key role in antigen recognition, which facilitates antibody design.

 

Figure 7 | iLabPower Sequence Editor shows protein biochemistry and CDR region.

 

Comparative Analysis

  •  BLAST

Blast analysis is a cornerstone of bioinformatics analysis, which has been widely used in basic evolutionary and developmental research, as well as clinical molecular diagnostics and design of new biological drugs. iLabPower Sequence Editor supports one-click jumping, automatically submits the target sequence fragments as query in NCBI-blastn page, and predicts the query sequence by comparing with NCBI database. Possible functions.

  •  Dual Sequence Alignment

iLabPower Sequence Editor supports dual sequence alignment of DNA and amino acid sequences to find the affinity between the two sequences. The comparison algorithm and parameters can be adjusted individually, and the comparison results can be visualized to show the conserved homologous regions and highly variable regions at a glance.

 

Figure 8 | iLabPower Sequence Editor Dual Sequence Comparison Results

New biopharmaceuticals have demonstrated unparalleled effectiveness and potential in the treatment of once-unsolved diseases, such as cancer and genetic diseases. iLabPower Sequence Editor, with its high efficiency, ease-of-use, and safety design concepts, has undoubtedly brought a new path for innovative research in laboratories and biopharmaceutical companies. It realizes that sequence design work can be done in one go, from upstream design to downstream testing, on a platform with highly controllable data security and reproducibility!

In addition, based on the in-depth understanding of the needs and pain points in the field of bio-new drug R&D, NeoTrident is also constantly upgrading the interaction and convenience of the software, enriching the bioinformatics functions provided by the software, and is committed to escorting the intellectual property rights and rapid research and development of China’s bio-innovative drugs!